Galapagos to present promising findings in cystic fibrosis programs at NACFC 2015
Five poster presentations cover progress and depth of discovery and development efforts in CF
Mechelen, Belgium; 8 October 2015 - Galapagos NV (Euronext & NASDAQ: GLPG) is present with a strong delegation presenting or contributing to five posters at the North American Cystic Fibrosis Conference (NACFC) in Phoenix this week.
Thursday, 8 October 11.50 AM - 1.50 PM MST
Friday, 9 October 7.30 AM - 8.45 AM
Potentiators: how do they impact the fate of CFTR during biogenesis?
Insights are presented on the contribution of GLPG1837 to the rescue of F508del CFTR
Insight into the mechanisms of correctors and potentiators
Galapagos and Abbvie developed new tools to better understand the mechanism of action of correctors and potentiators in its CF portfolio
Using BLISS analysis to categorize corrector-corrector interactions
Galapagos and AbbVie disclose the usage of a modelling tool to categorize interactions between candidate corrector compounds in their CF program
Safety, tolerability and pharmacokinetics of a novel CFTR Potentiator GLPG1837 in healthy volunteers
Galapagos presents safety and tolerability of GLPG1837 in healthy human volunteers, paving the path for the Phase 2 study in Class III mutation patients to start by end 2015. More information on this poster will be published later during the conference.
Saturday, 10 October 7.30 AM - 8.45 AM
Novel Potentiators Augment Efficacy of Translational Readthrough in CFTR Nonsense Mutations
Promising pre-clinical data using Galapagos potentiators on Class I (nonsense) CFTR mutations is presented
These posters will be made available on the Galapagos website, www.glpg.com, shortly following the presentation sessions.
The North American Cystic Fibrosis Conference is sponsored by the Cystic Fibrosis Foundation:
About cystic fibrosis (CF)
CF is a rare, life-threatening, genetic disease that affects approximately 80,000 patients worldwide and approximately 30,000 patients in the United States. CF is a chronic disease that affects the lungs and digestive system. CF patients, with significantly impaired quality of life, have an average lifespan approximately 50% shorter than the population average, with the median age of death at 27. There currently is no cure for CF. CF patients require lifelong treatment with multiple daily medications, frequent hospitalizations and ultimately lung transplant, which is life-extending but not curative. CF is caused by a mutation in the gene for the CFTR protein, which results in abnormal transport of chloride across cell membranes. Transport of chloride is required for effective hydration of epithelial surfaces in many organs of the body. Normal CFTR channel moves chloride ions to outside of the cell. Mutant CFTR channel does not move chloride ions, causing sticky mucous to build up on the outside of the cell. CFTR dysfunction results in dehydration of dependent epithelial surfaces, leading to damage of the affected tissues and subsequent disease, such as lung disease, malabsorption in the intestinal tract and pancreatic insufficiency.
Galapagos (Euronext & NASDAQ: GLPG) is a clinical-stage biotechnology company specialized in the discovery and development of small molecule medicines with novel modes of action, with a pipeline comprising three Phase 2 programs, two Phase 1 trials, five pre-clinical studies, and 20 discovery small-molecule and antibody programs in cystic fibrosis, inflammation, and other indications. Filgotinib is an orally-available, selective inhibitor of JAK1 for the treatment of rheumatoid arthritis and potentially other inflammatory diseases. Galapagos has reported good activity and a favorable safety profile in both the DARWIN 1 and 2 trials in RA. Galapagos is preparing to enter Phase 3 studies in RA and to report Phase 2 topline results with filgotinib in Phase 2 in Crohn's disease. In the field of cystic fibrosis, AbbVie and Galapagos signed a collaboration agreement to develop and commercialize molecules that address mutations in the CFTR gene. Potentiator GLPG1837 has completed a Phase 1 trial, and corrector GLPG2222 is expected to enter Phase 1 by end 2015. GLPG1205, a first-in-class inhibitor of GPR84 and fully-owned by Galapagos, will report topline results in Q4 2015 from a Phase 2 proof-of-concept trial in ulcerative colitis patients. GLPG1690, a fully proprietary, first-in-class inhibitor of autotaxin, has shown favorable safety in a Phase 1 trial and is expected to enter Phase 2 in idiopathic pulmonary fibrosis. The Galapagos Group, including fee-for-service subsidiary Fidelta, has approximately 400 employees, operating from its Mechelen, Belgium headquarters and facilities in The Netherlands, France, and Croatia. More info at www.glpg.com
Elizabeth Goodwin, VP IR & Corporate Communications
Cell: +1 781 460 1784
Evelyn Fox, Director Communications
Tel: +31 6 53 591 999
Galapagos forward-looking statements
This release may contain forward-looking statements, including statements regarding the promising findings demonstrated in the Company's product candidates for cystic fibrosis. Galapagos cautions the reader that forward-looking statements are not guarantees of future performance. Forward-looking statements involve known and unknown risks, uncertainties and other factors which might cause the actual results, financial condition and liquidity, performance or achievements of Galapagos, or industry results, to be materially different from any historic or future results, financial conditions and liquidity, performance or achievements expressed or implied by such forward-looking statements. In addition, even if Galapagos' results, performance, financial condition and liquidity, and the development of the industry in which it operates are consistent with such forward-looking statements, they may not be predictive of results or developments in future periods. Among the factors that may result in differences are the inherent uncertainties associated with competitive developments, clinical trial and product development activities and regulatory approval requirements (including that data from Galapagos' ongoing clinical research programs in cystic fibrosis may not support registration or further development of potentiators and/or correctors due to safety, efficacy or other reasons), Galapagos' reliance on collaborations with third parties (including its collaboration partner, AbbVie, who may not devote sufficient resources to the development and commercialization of the cystic fibrosis programs), and estimating the commercial potential of our product candidates. A further list and description of these risks, uncertainties and other risks can be found in the company's Securities and Exchange Commission filing and reports, including in the company's prospectus filed with the SEC on May 14, 2015 and future filings and reports filed by the company with the Securities and Exchange Commission. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements. These forward-looking statements speak only as of the date of publication of this document. Galapagos expressly disclaims any obligation to update any such forward-looking statements in this document to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements, unless specifically required by law or regulation.